Effect of
clofibrate on prolonged jaundice of term neonates.
When health advice alone was not effective, men in the intervention group also received drugs recommended at that time to lower blood pressure (beta-blockers and diuretics) and lipids (
clofibrate and probucol).
It was led by Professor Michael Oliver of the University of Edinburgh, Scotland, and tested the lipid-lowering drug
clofibrate. The blood cholesterol of 30,000 healthy, middle-aged men from Edinburgh, Prague, and Budapest was analyzed for cholesterol levels.
A wide variety of drugs are associated with SIADH, including chlorpropamide,
clofibrate, carbamazepine, vincristine, selective serotonin reuptake inhibitors, tricyclic anti-depressants, and NSAIDs [3].
Similar results on insulin/glucagon ratio, due to reduced insulin secretion rather than increase glucagon secretion, after stimulation with arginine, were observed in health subjects [41] and hypertriglyceridemic patients [42] treated with 2 grams of
clofibrate for 7 and 2-4 months, respectively.
([section][section]) Nonstatin lipid-lowering drugs included Niacin, Gemfibrozil, Fenofibric Acid,
Clofibrate, Colesevelam, Colestipol, Cholestyramine, and Cholestyramine/Sorbitol.
Clofibric acid, the active metabolite of
clofibrate (2), is a dual activator of PPAR[alpha] and PPAR[gamma], possessing tenfold selectivity for PPAR[gamma].
Fukushima, "Promoting effect of the peroxisome proliferator,
clofibrate, but not di(2-ethylhexyl)phthalate, on urinary bladder carcinogenesis in F344 rats initiated by N-butylN-(4- hydroxybutyl)nitrosamine," Japanese Journal of Cancer Research, vol.
There are some cases in literature reporting use of alternative treatments like carbamazepine [20], chlorpropamide [21,22], and
clofibrate [21, 23] for management of central diabetes insipidus.
clofibrate - a drug (trade name Atromid-S) that reduces lipids in the blood serum; used to treat some cardiovascular diseases