clo·za·pine

(klō′zə-pēn′, -pĭn)

An antipsychotic drug, C₁₈H₁₉ClN₄, used as a sedative and in the treatment of schizophrenia.

[c(h)lo(ro)- + alteration of (dia)zepine, seven-member ring containing two nitrogens; see benzodiazepine.]

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

clozapine

(ˈkləʊzəˌpiːn)

(Medicine) a sedative used to treat schizophrenia

Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

ThesaurusAntonymsRelated WordsSynonymsLegend:

Noun

clozapine - an antipsychotic drug (trade name Clozaril) used as a sedative and for treatment-resistant schizophrenia; know to have few side effects

Clozaril

antipsychotic, antipsychotic agent, antipsychotic drug, major tranquilizer, major tranquilliser, major tranquillizer, neuroleptic, neuroleptic agent, neuroleptic drug - tranquilizer used to treat psychotic conditions when a calming effect is desired

Translations

clozapine

n clozapina

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References in periodicals archive

Pimavanserin (Nuplazid), an atypical antipsychotic approved to treat hallucinations and delusions in Parkinson's disease, shows promise as a treatment for patients with refractory schizophrenia who fail to respond to clozapine, a retrospective study suggests.

Atypical used in Parkinson's lifts hallucinations, delusions

Our clinical team made a serendipitous discovery about the efficacy of pimavanserin in patients with schizophrenia who failed to respond to clozapine therapy

Pimavanserin: A potentially safer alternative to clozapine for refractory hallucinations and delusions

Cardiomyopathy and myocarditis are rarely seen but are potential mortal cardiotoxic effects of antipsychotic medication which are most commonly reported with clozapine treatment (9,10).

Olanzapine Associated Acute Peripheral Edema and Pericardial Effusion: A Case Report

He had been prescribed clozapine - anti-psychotic medication for schizophrenia - since 2013, which coroner for North Wales East and Central, John Gittins concluded had resulted in his death after toxic levels were found in his blood.

Toxic level of medicine killed man by accident

He had been prescribed clozapine - antipsychotic medication for schizophrenia - since 2013, which coroner for North Wales East and Central, John Gittins concluded had resulted in his death after toxic levels were found in his blood.

Toxic level of medicine killed man by accident

4, 2018 (HealthDay News) -- Remission can be achieved for most cases of schizophrenia and schizophreniform disorder with amisulpride and clozapine, according to a study published online Aug.

Remission of Schizophrenia Seen With Amisulpride, Clozapine; Symptomatic remission achieved for most with sequential administration of amisulpride, clozapine

Clozapine is a second-generation antipsychotic agent, which is considered to be more effective than other antipsychotics against treatment-resistant schizophrenia.

Then, clozapine was started in a dose up to 425 mg daily leading to serum levels of 587 ng/mL (reference value: 50 to 700 ng/mL), with no clinical signs of response after 33 weeks.

Capgras syndrome in a first-episode, late-onset and super-refractory schizophrenia case

Clozapine is an atypical antipsychotic that is used to treat schizophrenia that is refractory to other psychiatric medications.

A Rare Presentation of Clozapine-Induced DRESS Syndrome

A 58-year-old female with hypertension, hyperlipidaemia, and type two diabetes presented with atypical central chest pain seven days after commencing clozapine for refractory schizophrenia.

Clozapine-Induced Myocarditis or Acute Coronary Syndrome? Optical Coherence Tomography to the Rescue