Management of interstitial lung disease associated with
connective tissue disease. BMJ 2016; 352: h6819.
Among all
connective tissue diseases, SLE is the second most common disease after systemic sclerosis in with PAH is common and affect disease prognosis.11 The prevalence of PH in SLE was 2.8-23.3%.9 A comparative study was conducted in which various pulmonary manifestations in SLE patients have been studied and pulmonary hypertension was found to be one of the important complication in such patients.12 In another meta-analysis of various studies, it was found that PAH was found in 8% of SLE patients.13 Various predictors of PAH are compared which are found directly with PAH, such as nephritis, serositis (pleural and pericardial effusion), raynaud phenomenon and rheumatoid factor).
So as far as RD is concerned he is not yet off the hook from CTD, but I hope it is not CTD as the presence of vasculitis in
connective tissue disease like lupus often denotes active disease and possibly a poorer prognosis.
Md Yuzaiful Md Yusof, MBChB, of the Institute of Rheumatic and Musculoskeletal Medicine at the University of Leeds (England) and his colleagues evaluated long-term data from musculoskeletal ultrasound and blood and skin biopsy samples of 118 patients at risk of developing autoimmune
connective tissue disease (AICTD).
Idiopathic nonspecific interstitial pneumonia: lung manifestation of undifferentiated
connective tissue disease? Am J Respir Crit Care Med.
Keywords: Mixed
connective tissue disease (MCTD), Un-differentiated
connective tissue disease (UDCT), anti-ribonucleoprotien antibody (RNP).
Danoff, "Management of interstitial lung disease associated with
connective tissue disease," BMJ, vol.
Fuertes, "Mixed
connective tissue disease in a patient with Castleman disease and Hodgkin lymphoma: excellent clinical response to rituximab," Actas Dermo-Sifiliograficas, vol.
Table 1: Clinical and serological markers that predict the evolution to each definite
connective tissue disease (CTD).
* Inflammatory diseases other than ankylosing spondylitis (including
connective tissue diseases, chronic inflammatory lung and respiratory diseases, etc.),
A case of undifferentiated
connective tissue disease: Is it a distinct clinical entity?
Evaluation of interstitial lung disease in mixed
connective tissue disease (MCTD).