The optimal anti convulsant for the management of severe pre eclampsia and eclampsia was disputed, till the Eclampsia Collaborative Group published its results in 1995, showing clearly that magnesium sulphate was more efficacious than phenytoin or diazepam.
The sum of PTZ (2 mg/kg) required at threshold or tonic-clonic convulsion was calculated by following parameters: duration of convulsant infusion, infusion speed, the weight of the animal and the concentration of convulsant in the injected liquid (7).
METHODS AND RESULTS: By screening the affinity of RDX for a number of neurotransmitter receptors, we found that RDX binds exclusively to the picrotoxin convulsant site of the [gamma]-aminobutyric acid type A ([GABA.sub.A]) ionophore.
A previously healthy 15-month-old girl in New York City was rendered severely neurologically damaged after ingesting an imported rodenticide containing the convulsant poison tetramethylenedisulfotetramine (TETS), the CDC reported (MMWR 5410]:199-200, 2003).
This report describes the first known case in the United States of exposure to a Chinese rodenticide containing the toxin tetramethylenedisulfotetramine (TETS), a convulsant poison.
Absinthium is convulsant and was inspirationally used by artists and poets.1 In addition some species of Asteraceae family have antioxidant and acetylcholinesterase inhibitory effect.4
To investigate safer agents, we used a GABA-A inverse agonist (a5IA) to specifically target the a5 subunit of GABA-A receptors in Ts65Dn mice, a classical animal model of DS and we found that the drug had no convulsant effects and did not promote any side effects on sensory-motor and anxiety-related behaviours.
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