Cyproheptadine, at 4-16 mg, may be helpful when sleep disturbance is prominent, and in some cases may reverse sexual dysfunction, said Dr.
Therapy of brown spider envenomation: A controlled trial of hyperbaric oxygen, dapsone, and
cyproheptadine. Ann Emerg Med 1995;25:363-8.
These include doxepin, fluvoxamine, imipramine, mirtazapine, nortriptyline, paroxetine, protriptyline, sertraline, trazodone, venlafaxine,
cyproheptadine, diltiazem, ibuprofen, tiagabine, topiramate, and Botox (botulinum toxin type A).
Cyproheptadine has been shown effective causing appetite stimulation in debilitated, asthmatic children in doses of 8 mg orally three times daily.
Used to treat serotonin syndrome,
cyproheptadine's antagonism of serotonin 2A receptors has varying efficacy for reducing nightmares.
Although a number of studies have evaluated various appetite stimulants--megestrol, dronabinol (Marinol),
cyproheptadine (Periactin), thalidomide (Thalomid), pentoxifylline (Pentoxil/ Trental), nandrolone decanoate (DecaDurabolin), oxandrolone (Oxandrin), and corticosteroids--in patients with AIDS, anorexia cachexia syndrome, and advanced cancer, only megestrol has been studied in malnourished elderly patients.
Consider rotating antihistamines, such as
cyproheptadine, doxepin, and diphenhydramine, if one stops working.
Cyproheptadine (Periactin) can prevent nightmares if given to children at a dosage of 4 mg just before bedtime, Dr.
Ogawa, T., Nagao, T., Kashiwabara, K., Fukiwara, Y., Harada, T., Otsuki, S.: Tardive dyskinesia and neurotransmitters effects of sodium valproate,
cyproheptadine, oxypertine, hydroxyzine pamoate and Ca-hopatenate on monoamine metabolites, cyclic nucleotides and gammaaminobutyric acid in human cerebrospinal fluid.
The patient's vestibular symptoms were brought under control with
cyproheptadine. The results of pure-tone audiometry and speech testing were normal.
TABLE Physiologic, pharmacologic, and pathologic causes of an elevated serum prolactin level (1) PHYSIOLOGIC Pregnancy Ectopic pregnancy Lactation Nipple stimulation Stress Sleep disorder PHARMACOLGIC Dopamine receptor antagonists: phenothiazines, butyrophenones, thioxanthene, risperidone, metoclopramide, sulpiride, pimozide Dopamine-depleting agents: [alpha]-methyldopa, reserpine Hormones: estrogens, antiandrogens Others: danazol, isoniazid, verapamil,
cyproheptadine, opiates, H2-blockers (cimetidine), cocaine and marijuana, tricyclic antidepressants PATHOLOGIC Acromegaly Alcoholic cirrhosis Chest wall trauma or tumor Herpes zoster Hypothalamic and pituitary stalk disease Hypothyroidism Pituitary tumors: prolactinomas, adenomas Polycystic ovarian syndrome Renal failure Sarcoidosis