As shown in Table 3, most patients (93.8%) controlled the interval between eye drops more than 5 minutes; however, only 3.5% patients knew to press the dacryocyst area after instilling the eye drops.
It showed that younger age, better education, better visual acuity, knowledge of pressing the dacryocyst area to occlude the punctum, and prior instruction regarding using eye drops were the factors significantly associated with a good technique (p < 0.05 for all).
Unable to press the dacryocyst area again increased the bypass outflow of the medicine and systemic absorption.
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