Secukinumab is effective in reducing
dactylitis and enthesitis using multiple measures in patients with psoriatic arthritis: results of a phase 3 randomized, multicenter, double-blind, placebo-controlled study (FUTURE 2).
Dactylitis is swelling of the fingers and toes that can cause them to have a sausage-like appearance, and it's sometimes called sausage digit.
In addition to the primary endpoint of ACR20 response at week 24, multiple secondary endpoints were assessed that included ACR50/70, resolution of soft tissue inflammation (enthesitis and
dactylitis), disease activity (DAS-28 CRP), improvement in physical function (HAQ-DI), skin clearance, and quality of life (SF-36 PCS and MCS).
The medical condition
dactylitis is the inflammation of which part of the body?
In a previous Saudi study, acute painful crisis and
dactylitis were significantly more common among Eastern province patients than Western province patients; moreover, the onset was significantly later in Eastern province patients.
* S = Stiffness lasting >30 minutes after waking in the morning or after a period of inactivity, or Sausage digits (
dactylitis)
Almost 30% of psoriasis patients are affected by psoriatic arthritis which is a chronic immune mediated, inflammatory disease and is characterized by peripheral and axial arthritis,
dactylitis and enthesists.
Peripheral arthritis, enthesitis,
dactylitis as well as extraarticular manifestations of spA including psoriasis, anterior uveitis, and inflammatory bowel diseases may be present.