de·dif·fer·en·ti·a·tion

(dē′dĭf-ə-rĕn′shē-ā′shən)

n. Biology

Reversion of a specialized cell or tissue to an unspecialized form. Dedifferentiation may occur before the regeneration of appendages in plants and certain animals and in the development of some cancers.

de′dif·fer·en′ti·ate′ v.

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

dedifferentiation

(diːˌdɪfəˌrɛnʃɪˈeɪʃən)

(Biology) the reversion of the cells of differentiated tissue to a less specialized form

Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

de•dif•fer•en•ti•a•tion

(diˌdɪf əˌrɛn ʃiˈeɪ ʃən)

n. Biol.

the loss of specialized form or condition previously acquired during development.

[1915–20]

de`dif•fer•en′ti•ate`, v.i. -at•ed, -at•ing.

ThesaurusAntonymsRelated WordsSynonymsLegend:

Noun

dedifferentiation - the loss of specialization in form or function

adaption, adaptation, adjustment - the process of adapting to something (such as environmental conditions)

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References in periodicals archive

In patients on calcineurin inhibitors, the risk of keratinocyte carcinomas appears to be related to a direct effect of these agents on keratinocyte dedifferentiation. Belatacept is not believed to have any direct effects on keratinocytes, according to Mr.

Belatacept may mitigate skin cancer risk in transplant patients

Diffusion-weighted MR imaging: diagnosing atypical or malignant meningiomas and detecting tumor dedifferentiation. AJNR.

Diagnostic accuracy of diffusion weighted MRI in differentiating benign and malignant meningiomas

(24) Some tumors reveal features of dedifferentiation, such as prominent nucleoli, sarcomatoid change, or coagulative necrosis.

Succinate Dehydrogenase-Deficient Renal Cell Carcinoma

This suggests a dedifferentiation of the tumor (6).

Tonsillar and Parotid Gland Metastases of Breast Cancer: Two Cases and A Literature Review

CSC is tailored with unlimited self-renewal; slow dividing capacity and is envisioned to originate either by several genetic and epigenetic alterations or precancerous phenotypic transformation in a normal, tissue-specific stem cell or by dedifferentiation of mature tumour cells.

FIELD CANCERIZATION--AN APPRAISAL OF CONCEPTS AND RESEARCH

They identified a similar K-RAS mutation in anaplastic carcinoma and previously resected mucinous tumor, and they suggested that it may show dedifferentiation rather than a collision tumor.

Appendiceal mucinous cystadenocarcinoma with mural nodules of anaplastic carcinoma and K-RAS mutation

Epithelial-to-mesenchymal transition and estrogen receptor a mediated epithelial dedifferentiation mark the development of benign prostatic hyperplasia.

MicroRNA-340 Inhibits Epithelial-Mesenchymal Transition by Impairing ROCK-1-Dependent Wnt/[beta]-Catenin Signaling Pathway in Epithelial Cells from Human Benign Prostatic Hyperplasia

Clinically nonmetastatic renal cell carcinoma with sarcomatoid dedifferentiation: natural history and outcomes after surgical resection with curative intent.

Secondary involvement of the gastrointestinal tract by renal cell carcinoma

Also, dedifferentiation with loss of radioiodine-avidity and finally anaplastic transformation are poor-prognosis events in DTC (2).

I-131 Radiation-Induced Myelosuppression in Differentiated Thyroid Cancer Therapy: Diferansiye Tiroid Kanser Tedavisinde I-131 Radyasyona Bagli Miyelosupresyon

Involvement of cellular dedifferentiation in cancer development

The causal relationship between epigenetic abnormality and cancer development: in vivo reprogramming and its future application

The analysis also identified molecules whose expression was associated with dedifferentiation (loss of differentiated phenotype) for some cancer types.

New Methodology Measures Tumor Aggressiveness, Risk Of Relapse

Occasional cases of dedifferentiation from a low-grade to a high-grade malignancy have been reported.

Central Acinic Cell Carcinoma of the Mandible Simulating as Benign Odontogenic Lesion: A Case Report