The DecisionDx-Melanoma test requires a
dissectible area of tumor cells to be identifiable histologically, which is then microdissected off of a 5-[micro]m-thick histologic section.
Multiple methods have been used to describe the coronary paths and ramifications, such as direct dissection after formaldehyde fixation Crick et al.,
dissectible casting after polymeric repletion (Moore, 1930; Blair, 1961; Ozgel et al., 2004; Moura Junior et al., 2009; Oliveira et al., 2010; Gomez & Ballesteros, 2013); cardiac tissue digestion with corrosive agents (Blair; Bertho & Gagnon, 1964; Roldan & Blanquez Layunta, 1982; Weaver et al., 1986), clearing with wintergreen oil (Abramson et al, 1933; Moore et al., 2008) and radiological tools applied to obtain post mortem images of the heart (Rodrigues et al., 2005).
In all experimental groups, the surgical sites were macroscopically examined for adhesion grading based on the length, density and, range of motion (Grade 1: No adhesion, Grade 2: Adhesion easily
dissectible from the surrounding tissues, Grade 3: Adhesion not easily
dissectible from the surrounding tissues, Grade 4: Adhesion involving 35-60% of the affected site, Grade 5: Adhesion involving more than 60% of the affected site) (LIU et al., 2008).
In spite of high frequency of intracranial arterial involvement, arterial narrowing is rare in intracranial chordomas, a finding reflective of the fact that these tumors are soft and easily
dissectible from adjacent vessels.
Individual structures are reconstructed in accurate 3D, resulting in an unprecedented level of real accurate anatomy,
dissectible in 3D.