Abnormal tonicity of muscle, characterized by prolonged, repetitive muscle contractions that may cause twisting or jerking movements of the body or a body part.
(Pathology) a neurological disorder, caused by disease of the basal ganglia, in which the muscles of the trunk, shoulders, and neck go into spasm, so that the head and limbs are held in unnatural positions
[from dys- + -tonia from Greek tonos tension, from teinen to stretch]
- Newark, California-based botulinum toxin products developer Revance Therapeutics, Inc.(NASDAQ: RVNC) has initiated patient dosing in the ASPEN phase 3 clinical program for its investigational drug candidate DaxibotulinumtoxinA for Injection (RT002) for the treatment of cervical dystonia, a movement disorder of the neck, the company said.
Dystonia is rarely psychogenic, but this etiology is suggested when clinical characteristics are inconsistent and incongruous with a classical disorder.
Idiopathic (primary) cervical dystonia (CD) is a coercive undesirable pathology characterized by involuntary sustained or intermittent contractions of the muscles of the neck causing twisting movements and abnormal head and neck postures (1-3).
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