Postexposure treatment with inhibitors of TRP vanilloid, an ion channel expressed in pulmonary endothelial cells, had anti-inflammatory effects in Cl[sub]2-exposed mice and inhibited vascular leakage, AHR, and increase in
elastance, therefore improving blood oxygen saturation.[44]{Figure 2}
Left ventricular (LV)
elastance [systolic blood pressure/LV end systolic volume (LVESV)] and arterial
elastance (systolic blood pressure/LV stroke volume) were calculated as detailed by Chantler et al.
As shown in Table 2, the load-dependent (ejection fraction, preload adjusted maximal power, end systolic volume, and end diastolic volume) and load-independent (maximal
elastance, end systolic pressure-volume ratio, preload recruitable stroke work, and end systolic
elastance) indices in both cell-seeded patch groups were substantially improved.
evaluated breast cancer patients who received doxorubicin and/or trastuzumab therapy to determine chemotherapy-related cardiac dysfunction by using echocardiography-derived measures of arterial
elastance. They identified ventricular arterial coupling and circumferential strain as the predictors of chemotherapy-related cardiac dysfunction as a noninvasive strategy to identify high-risk patients [18].
MR-Intracranial pressure (ICP): a method to measure intracranial
elastance and pressure noninvasively by means of MR imaging: baboon and human study.
A "snapshot perturbation" maneuver was then used to measure the resistance (R), compliance (C), and
elastance (E) of the whole respiratory system.
Regarding GW0742, it was recently demonstrated that it can reverse the lung tissue damage induced by elastase in emphysema-model mice and improves respiratory function in mouse model: in particular, GW0742 increases the in vivo expression of surfactant proteins A and D, which are known alveolar type II epithelial cell markers, reduces the average distance between alveolar walls in the lungs, and improves tissue
elastance, as well as the ratio of the forced expiratory volume in the first 0.05 s to the forced vital capacity [33].
For b < 1, the Pao curve presents a downward concavity, suggesting a continuous decrease in
elastance during constant-flow inflation.
[5] Nichols W, Edwards D G 2001 Arterial
elastance and wave reflection augmentation of systolic blood pressure: deleterious effects and implications for therapy J.
How much of that displayed airway opening pressure was required to expand the lung and how much the chest wall are determined by their relative stiffness (
elastance).