Similarly, in rats with endotoxemia, the treatment with MSC (both intraperitoneal and intravenous application) ameliorated the myocardial depression and reduced both serum and myocardial levels of inflammatory mediators (TNF-[alpha], IL-1[beta], and IL-6).
suggested that acupuncture pretreatment improved the survival rate in rats with lethal endotoxemia, which involves the activation of the autonomic nervous system [17].
More specifically, heat-stressed animals are said to suffer reduced intestinal integrity and barrier function, increased systemic endotoxemia, inflammation problems, reduced lean tissue accretion, and lower fertility rates, among others.
The condition is linked to alterations in the gut microbiota, increased production of gut toxins such as ammonia and indoles, and endotoxemia, a condition associated with systemic inflammation and metabolic syndrome.
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