The University of Minnesota BMT Team has also observed a correlation between the
engraftment in the blood and
engraftment in the skin.
However, prolonged isolated thrombocytopenia (PT), which is defined as the
engraftment of all peripheral blood cell lines other than a platelet (PLT) count [greater than or equal to] 20 x [10.sup.9]/L or dependence on PLT transfusions for more than 90 days after allo-SCT, has a great impact on transplant outcomes, especially in haploidentical SCT settings.
He further said that Ashir 4 years old had transplant on same day but his blood counts did not show any evidence of bone marrow
engraftment (primary graft failure) which is well known complication of bone marrow transplant.
Our case represents favorable results that haploidentical
engraftment might have on patients' survival after
engraftment failure from the first allograft.
Besides providing an early heads up about
engraftment status, she added, this technique also could help patients avoid painful bone marrow biopsies to make sure donor cells have taken residence in the bones or at the very least help target those biopsies.
"We believe the primary goal of SCiStar, which was to observe the safety of OPC1 in cervical spinal cord injury patients and to accumulate data related to important factors such as optimal dosing levels, the immunosuppression regimen,
engraftment of the cells, and rates of motor recovery observed among different study subpopulations, have been successfully achieved and increases our confidence as we prepare to meet the FDA later this year to discuss the next trial design."
Unfortunately, the
engraftment success rate is relatively low because the tissues lose their vascularization and blood supply as islets are being processed before transplant.
Interestingly, in the present study, patients who received a higher dose of CD14+ monocytes had a higher probability of platelet
engraftment. Monocytes are bone marrow-derived mononuclear cells that give rise to macrophages.[34],[35] The previous studies have shown that monocyte/macrophages play an important role in bone homeostasis.[36],[37] Winkler et al .[38] observed that bone marrow macrophages are pivotal to maintain the endosteal HSC niche.
Use of Eltrombopag in Patients with Platelet
Engraftment Failure Following Second Allogeneic Peripheral Stem Cell Transplantation.
In the discussion, the sentence "the history of pre-transplant radiotherapy was significantly associated with delayed neutrophil
engraftment time" should read as "the history of pre-transplant radiotherapy was significantly associated with faster neutrophil
engraftment".