Lim, "Co-culture of stromal and erythroleukemia cells in a perfused hollow fiber bioreactor system as an in vitro bone marrow model for myeloid leukemia," Biotechnology and Bioengineering, vol.
Thus, for example, diosgenin has antiproliferativeactivity, namely, inprostatecancer(PC-3 and DU-145 cells) [23], colon carcinoma (HCT-116 and HT-29 cells) [24], erythroleukemia (HEL cells) [27], squamous carcinoma (A431, Hep2, and RPMI2650 cells) [28], hepatocellular carcinoma (HepG2 and HCC cells) [6,25,29], gastric cancer (BGC-823 cells) [30], lung cancer (A549 cells) [31], breast cancer (MCF-7) [6,32-34], and human chronic myeloid leukemia (CML) (K562 cells) [1].
Moreover, diosgenin induces megakaryocytic differentiation of human erythroleukemia cells through ERK and sonic hedgehog pathway activation (Fernandez-Zapico et al.
nucifera (typical A variety, commonly known as "olho-de-cravo", and the common variety) were tested on human erythroleukemia cell line K562 and Lucena 1, a multidrug-resistant (MDR) and vincristine-resistant derivative of K562.
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