Exocrine glands such as salivary glands, lacrimal glands and mammary glands secrete a variety of peptide growth factors which are crucial for their development, cellular proliferation, differentiation and healing (Kouidhi et al., 2012).
By definition, CF is a hereditary disorder affecting the exocrine glands. It causes the production of abnormally thick mucus, leading to the blockage of the pancreatic ducts, intestines and bronchi, and often resulting in respiratory infection.
The main histopathological feature of SS is lymphocytic infiltration of the exocrine glands, resulting in acinar cell death, probably through apoptosis.[1] The exact etiology and pathogenesis of SS are still not clear.
Sjogren's syndrome is a systemic autoimmune disorder characterized by a unique set of signs and symptoms predominantly caused by a cell-mediated autoimmunity against exocrine glands [7].
Primary Sjogren's syndrome (pSS) is a systemic autoimmune disease characterized by chronic inflammation of exocrine glands. At least onethird of pSS patients present with extraglandular systemic features including neurologic, articular, pulmonary, or renal manifestations.
Sjogren syndrome (SS) is a systemic autoimmune disease characterized by lymphocytic infiltration and destruction of exocrine glands associated with dryness of eyes and/or mouth.
Although the etiology of Sjogren's syndrome is not yet clear, B lymphocyte hyperreactivity, autoantibody production, and T cell lymphocytic infiltration to exocrine glands and other organs have been observed in patients diagnosed with Sjogren's syndrome [3, 4].
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