The study of 993 patients with 245 malignancies shows that Vermillion's second generation multivariate index assay, Overa, had superior sensitivity to the current standards of care, Risk of Malignancy Algorithm, or ROMA, and CA125, in detecting ovarian cancer, and the lowest false-negative rate in correctly characterizing ovarian malignancy risk.
Second, with substantially more linkages than previous research, we use linked 2011 CPS ASEC and 2010 MSIS data to evaluate two components of measurement error affecting the undercount: false-negative error and false-positive error (Figure S1).
The likelihood of a false-positive or false-negative result declined sharply when all three tests were given, however; only about 2% of patients were misclassified in all three, David Llewellyn, PhD, and his colleagues reported.
Recent past has seen multiple, large scale, multi-institutional studies revealing SLN biopsy's false-negative rates ranging from 5.5% to 16.7%4-7, higher than the target (<5%) set by the 2005 guidelines of the American society of clinical oncology2.
Parents of children with false-negative M-CHAT results rated their children's gross and fine motor skills and social and communication skills at 18 months as less developed than did parents of children with true-negative screens.
Øien, from the Arctic University of Norway in Tromsø, and colleagues compared sex-stratified developmental and temperamental profiles at 18 months in children screening negative for ASD on the M-CHAT but later receiving a diagnosis of ASD versus those without a later ASD diagnosis (false-negative group versus true-negative group).
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