Agranulocytosis, also known as agranulosis or granulopenia, is an acute condition involving a severe and dramatic decreasing of white blood cell counts, which is life threatening.
The aberrant composition of the isolated PBM cell fraction of this patient might have been caused by the granulocyte colony-stimulating factor that the patient had been receiving as treatment for grade 4 granulopenia. Analogously, low DPD activity (4.2 nmol * [mg.sup.-1] * [h.sup.-1]) was initially detected in PBM cells from patient 2 when she was suffering from grade 4 toxicity after treatment with 5FU.
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