The researchers discovered that
integrins, which are proteins that sit in cell membranes and link the internal skeleton of cells to the larger protein scaffolding of the surrounding tissue, trigger a newly described signaling cascade within the stem cells that causes them to begin rapidly proliferating.
It is a family of glycoproteins which influences the cell surface
integrins levels of keratinocytes.9
Integrins are transmembrane receptors that form cell-substratum adhesions by linking the ECM to the underlying cytoskeleton through various scaffolding proteins [3].
Podocyte attachment to the glomerular basement membrane involves interactions between
integrins and specific matrix ligands [12].
Although TM4SF5 binds to many different membrane receptors including CD151, growth factor receptors, and
integrins [6], TM4SF5 itself can trigger intracellular focal adhesion kinase (FAK) [12] and c-Src-dependent signaling [13].
Podocytes, which are the most vulnerable components of the glomerular filtration, adhere to the underlying GBM via cell-matrix adhesion receptors, including [alpha]-dystroglycan; syndecan-4; type XVII collagen;
integrins [alpha]3[beta]1, [alpha]2[beta]1, and [alpha]v[beta]3; and a variety of other linker, scaffolding, and signaling proteins [52].
The company was founded to exploit the therapeutic potential of RGD-binding
integrin antagonists by leveraging groundbreaking discoveries on the role of these
integrins in the pathogenesis of fibrosis.
Fibronectin- and vitronectin-induced microglial activation and matrix metalloproteinase-9 expression is mediated by
integrins alpha5beta1 and alphavbeta5.
The researchers determined that the function of
integrins (specifically, the protein [beta]1-integrin) is absolutely crucial for maintaining the cycle of hibernation, activation, proliferation, and then return to hibernation, in muscle stem cells.
Surface proteins called
integrins - that normally anchor tumours to one place - help them survive.
Experts found the free floating cells survive because of a change that happens to surface proteins called
integrins which normally keep tumours anchored to one place.