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Noun

iron overload - pathology in which iron accumulates in the tissues; characterized by bronzed skin and enlarged liver and diabetes mellitus and abnormalities of the pancreas and the joints

bronzed diabetes, hemochromatosis, iron-storage disease

pathology - any deviation from a healthy or normal condition

classic hemochromatosis, idiopathic hemochromatosis - inherited form of hemochromatosis

acquired hemochromatosis - hemochromatosis resulting from repeated transfusions or from excessive intake of foods containing iron

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References in periodicals archive

Iron overload remains the cause of morbidity and mortality in patients with BT major and thalassaemia intermedia.

Co-existing iron deficiency/overload in beta-thalassemia trait

The aim of the study was to find out the frequency of gene mutation of HFE in Pakistan in iron overload patients.

FREQUENCY OF HFE GENE MUTATION IN IRON OVERLOAD PATIENTS

These transfusions carry the risk of progressive multi-organ damage due to unavoidable iron overload. ZYNTEGLO is a one-time gene therapy that addresses the underlying genetic cause of TDT and offers patients 12 years and older who do not have a beta0/beta0 genotype the potential to become transfusion independent, which once achieved is expected to be life-long.

Bluebird Bio announces EU conditional marketing authorization for ZYNTEGLO

Among the topics are iron chelation for iron overload in thalassemia, iron oxide nanoparticle formulations for supplementation, building a Trojan horse: siderophore-drug conjugates for treating infectious diseases, copper depletion as a therapeutic strategy in cancer, and chemical and clinical aspects of metal-containing antidotes for poisoning by cyanide.

Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic

Although transfusions are life savers for such patients but at the same time lead to iron overload and expose the patients to many other complications like hypersplenism, chronic hepatitis, human immuno-deficiency virus (HIV), venous thrombosis and osteoporosis6.

FREQUENCY OF IRON OVERLOAD COMPLICATIONS IN BETA THALASSEMIA MAJOR PATIENTS

Deferasirox Tablets for Oral Suspension are indicated for the treatment of chronic iron overload due to blood transfusions (transfusional hemosiderosis) in patients 2 years of age and older.

Teva Launches of a Generic Version of Exjade Tablets for Oral Suspension in the United States

Experts believe that the work, which has involved designing a brand new molecule with potential to be added to sun cream, could benefit those with FriedrichaACAOs Ataxia (FA), as well as those with other disorders characterised by mitochondrial iron overload, notably Wolfram Syndrome and Parkinson's disease, where UVA rays from the sun may pose particular challenges.

New study could offer protection to patients with rare genetic disease

Males and post-menopausal women have no mechanism to excrete excess iron, relying on tightly regulated absorption to prevent iron overload. (2)

Iron--too much of a good thing? Too much iron in the body causes damage and disease

In collaboration with the Ministry of Health, Oman Novartis brought haematology experts who treat iron overload patients to Muscat, Oman at the Hormuz Grand Hotel.

MAJOR BREAKTHROUGH FOR THALASSAEMIA PATIENTS IN OMAN

To avoid complications, the iron overload is decreased; phlebotomy is the cornerstone in treatment (6).

Should we use proton pump inhibitors as an add-on treatment in hereditary hemochromatosis?