A broad-spectrum antifungal agent, C26H28Cl2N4O4, administered as a topical treatment or as a second-line oral treatment for a variety of fungal infections.
The Committee considered that this constitutes a clinically relevant advantage." The medications ketoconazole, metyropone and pasireotide are approved in the EU for the treatment of one or more aetologies of Cushing's syndrome.
Objective: Comparison of efficacy of combination comprising 2% ketoconazole solution wash plus topical 1% clotrimazole versus topical 1% clotrimazole alone in management of patients with Pityriasis versicolor.
As part of the new agreement, the featured products include Stratford's KETO-C shampoo, flush, spray and wipes which help control dermatological issues which respond to ketoconazole and chlorhexidine.
In 2013, the United States Food and Drug Administration (US FDA) and the European Medicines Agency's Committee on Medical Products for Human Use (EMA-CHMP) concurrently issued safety warnings and limited the use of oral ketoconazole because of its association with increased risk of inducing hepatic injury, risk of drug interactions, and increased risk of adrenal insufficiency [1, 2].
Terbinafine and ketoconazole were evaluated in concentrations from 0.0234 to 480 [micro]g m[L.sup.-1] and from 0.0313 to 640[micro]g m[L.sup.-1], respectively, in RPMI-1640 medium buffered with MOPS [19, 20].
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