[25.] Wester CW, Okezie OA, Thomas AM, et al Higher-than-expected rates of lactic acidosis among highly active antiretroviral therapy-treated women in Botswana: Preliminary results from a large randomized clinical trial.
Serious side effects include lactic acidosis (a build-up of lactic acid in the blood); inflammation of the pancreas (pancreatitis) and low blood sugar (hypoglycemia).
Most clinicians are familiar with the common side-effects of peripheral neuropathy and hepatotoxicity, but lesser known, severe INH toxicity is characterised by recurrent seizures, lactic acidosis, coma and death.
Less commonly described cause of high anion-gap metabolic acidosis in alcoholics is lactic acidosis. Severe lactic acidosis following only ethanol intoxication is rarely described in literature.
Rumen lactic acidosis is a nutritional metabolic disease that causes great economic losses in ruminants and can evolve into subacute, acute, or chronic forms.
As for juice therapies, Villegas said they received a report of a cancer patient who died from severe lactic acidosis after taking large doses of mangosteen juice daily for a year.
To the Editor: A range of studies have demonstrated that symptomatic hyperlactataemia and lactic acidosis are associated with antiretroviral combinations containing stavudine.
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