Natural scaffold is in-turn classified into protein based biomaterials (collagen, fibrin, silk, gelatin, elastin, keratin, actin and myosin,
laminin and vitronectin) and polysaccharide based biomaterials (Agarose, alginate, hyaluronan, chitosan, amylase, dextran, cellulose and glycosaminoglycans).
OFM was shown to retain residual basement membrane components, such as
laminin, collagen IV and collagenous microarchitecture comprised of fibronectin, glycosaminoglycans and elastin.
Member Companies: Safari Circuits, Oliver-Tolas Healthcare Packaging, Keystone Solutions Group, DornerWorks, Koops, Grand Rapids Foam Technologies, Active Manufacturing, Creative Foam, Humphrey Products, Alticor/Access Business Group International, Amerikam, Amtech Electrocircuits, Autocam Medical, Emerald Medical, Extol, Firstronic, JR Automation Technologies, Kent Manufacturing,
Laminin Medical Products, Marketlab, Medbio, Michigan Spring & Stamping, Motion Dynamics Corporation, Packaging Compliance Labs, Ranir, Rose Medical, SSI Electronics, Grand Rapids SmartZone
E-cadherin,
laminin and collagen IV antibodies were obtained from Abeam (Cambridge, UK), [alpha]-SMA antibody was purchased from DAKO (Produktionsvej 42, DK2600 Glostrup, Denmark).
Naturally derived biopolymers such as derivatives of carbohydrates and collagen, elastin,
laminin, and fibronectin are used for drug delivery and skin soft tissue utilization.
Carcinoma cells have the ability to transform fibroblasts into reactive myofibroblasts, which synthesize different ECM components: collagen, fibronectin, tenascin, versican, galectin,
laminin and others.
Within the central nervous system, extracellular matrix substances such as collagen and
laminin promote the regeneration, differentiation, adhesion and migration of nerve fibers.
ECM consists of several distinct components (Figure 1) which can be divided into three groups: i) structural proteins, such as collagen and elastin, ii) specialized adhesion proteins, such as fibronectin, fibrilin, and
laminin, iii) glycosaminoglycans (GAG) and proteoglycans (PG).
The capsule is secreted by the cells it surrounds and is composed of
laminin, collagen IV, entactin/nidogen, and heparan sulfate proteoglycans including perlecan [1-3].