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Noun

major affective disorder - any mental disorder not caused by detectable organic abnormalities of the brain and in which a major disturbance of emotions is predominant

affective disorder, emotional disorder, emotional disturbance

folie, mental disorder, mental disturbance, psychological disorder, disturbance - (psychiatry) a psychological disorder of thought or emotion; a more neutral term than mental illness

clinical depression, depressive disorder, depression - a state of depression and anhedonia so severe as to require clinical intervention

manic disorder, mania - a mood disorder; an affective disorder in which the victim tends to respond excessively and sometimes violently

bipolar disorder, manic depression, manic depressive illness, manic-depressive psychosis - a mental disorder characterized by episodes of mania and depression

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References in periodicals archive

Other medications have been identified as modifying suicide risk (Table 2).(14-20) Among patients with major affective disorders, lithium has been shown to reduce suicidal acts by 93%, suicide attempts by 93%, and suicide completions by 82%.(14) Lithium produces the largest suicide risk reduction in unipolar depression, at 100%, followed by bipolar II disorder (82%) and bipolar I disorder (67%).(15) Several studies have demonstrated that lithium can reduce the mortality rate from suicide for patients with affective disorders, and that this effect persists.(16,17)

Suicide assessment: Targeting acute risk factors; focus on time-sensitive factors that may respond to treatment

Familial cosegregation of major affective disorder and Darier's disease (keratosis follicularis).

Darier's Disease and Schizophrenia

No association of the tryptophan hydroxylase gene with bipolar affective disorder, unipolar affective disorder, or suicidal behavior in major affective disorder. Am J Med Genet 1998; 81:245-7.

American Psychiatric Association suicide guidelines state that the use of lithium for patients with recurrent major affective disorder is supported by "the strongest available evidence of major reductions in suicide risk of any currently employed psychiatric treatment."

Lithium: the unsung antisuicide medication