Comprehensive genomic analysis identifies pathogenic variants in
maturity-onset diabetes of the young (MODY) patients in South India.
In type 2 diabetes, which is also called as
maturity-onset diabetes, the insulin was produced from the pancreas in required amounts.
Maturity-onset diabetes of the young (MODY) is a monogenic subgroup of diabetes mellitus characterized by autosomal dominant inheritance, non-insulin diabetes onset usually before 25 years of age and decreased insulin production or secretion response to glucose.
Islet autoantibodies can discriminate
maturity-onset diabetes of the young (MODY) from Type 1 diabetes.
Along with these most common variations of the condition, Prof Hussain also outlined other types of the condition, including neonatal, mitochondrial, syndromic and MODY (
Maturity-Onset Diabetes of the Young).
Maturity-Onset Diabetes of the Young: Example of the Utility of Genetics in Precision Medicine
Ellard, "
Maturity-onset diabetes of the young (MODY): how many cases are we missing?" Diabetologia, vol.
Monogenic forms of diabetes (caused by mutations in single genes), including
maturity-onset diabetes of the young (MODY) and neonatal diabetes (diagnosed before 6 months of age), are rare, representing ~3.6% of all cases diagnosed under 30 years [3].
There are at least 13 subtypes of
Maturity-Onset Diabetes of the Young (MODY) known to date.
[14-16] Whether this association is due to an increased risk of
maturity-onset diabetes of the young (MODY) type 5 (also known as 'renal cyst and diabetes' syndrome) in this group of patients is worth exploring.
Obesityrelated diabetes is sometimes referred to as
maturity-onset diabetes because it's more common in older people.
Obesity-related diabetes is sometimes referred to as
maturity-onset diabetes because it's more common in older people.