Vitamin D plays its role through vitamin D receptor, which is expressed by melanocytes indicative of vitamin D role in the
melanogenesis (3).
Melanization can be different at high and low altitudes for three main reasons: 1) adaptations to different parasitic pressures, 2) nutrient availability to synthesize melanin or 3) abiotic conditions such as temperature regulating
melanogenesis (Schmid-Hempel, 2005).
In one study, patients who received narrow-band UVB had an increase in vitamin D levels that could contribute to photo-induced
melanogenesis, and an open-label study indicated that patients who took vitamin D daily (without phototherapy) for 6 months had an increase of repigmentation over time.
Consequently, prostatic epithelial cells have no capacity for
melanogenesis except for prostatic stromal cells.
The acute harmful effects of ultraviolet rays on the skin include damage to DNA, apoptosis, erythema, immunosuppression and an increase in pigmentation due to stimulation of
melanogenesis, while the long-term effects include photoaging and photocarcinogenesis.
To compare the effects of ECPS and CPS on the activity of intracellular tyrosinase and
melanogenesis in B16F10 melanoma cell model, the inhibitory potency of ECPS and CPS on melanin content and tyrosinase activity in [alpha]-MSH-stimulated B16F10 cells were examined.
Mimosine Dipeptide Enantiomsers: Improved Inhibitors against
Melanogenesis and Cyclooxygenase.
In this study, an unexpected link was found among gray hair, the transcription factor MITF or
Melanogenesis Associated Transcription Factor, and innate immunity.
Some studies have identified a serine-type protease inhibitor related to palmitoyltransferase that has an effect on
melanogenesis.[5] Among other known serine protease inhibitors (SERPINs), the enhanced stability of PAI-1 might play a role in the development of autoimmune disease and the pathophysiology of vitiligo.
There is actually a complex biochemical process involved called
melanogenesis which is controlled by enzyme tyrosinase.
MITF acts as a key regulator of
melanogenesis enzyme genes of the Tyr family and melanocyte differentiation.