One such novel player within the domain of aging is the
microRNA.
MicroRNAs are single stranded, bijou (18-25 nucleotides in length), non-protein-coding RNAs that negatively operate the process of gene expression by modifying post-transcriptional targets on messenger RNA.2 They embrace 1-5% of the human genome.3 Harries (2014) has comprehensively reviewed the role of
microRNA, affecting the nine major determinants of aging; 1) Genomic Alterations: Our genome has highly conserved DNA maintenance mechanisms which preserves the integrity of DNA from exogenous and endogenous insults.
Other genes also could be targets for this
microRNA, since these molecular regulators typically target more than one gene.
M2 PHARMA-April 20, 2018-InteRNA
microRNA Candidate INT-1B3 Causes Immune-System Activation, Tumor Regression, and Long Term Immunity
The aim of this preliminary study based on a small cohort of ONIHL was to compare the serum expression profiles of
microRNAs between ONIHL subjects and controls using
microRNA microarray assay.
For clinical application, gene replacement therapy with
microRNA mimics met many obstacles: the instability of therapeutic molecules, nonspecific inflammation, controlled release of therapeutic molecules, specificity and efficiency of the delivery systems [53].
Deregulation of
microRNA expression has also been associated with GDM; thus, these molecules could represent potential early diagnostic biomarkers, due to their high stability in body fluids and their accessibility from maternal blood throughout gestation [15].
The companys product categories include
microRNA research, incRNA research, mRNA research, DNA research, custom oligos and other reagent products.
Given that the pathogenesis of some diseases involves under or overexpression of
microRNAs (Table 1), the evaluation of
microRNA expression may be used in therapeutic planning.
According to the company, the application '185 claims hsa-miR-146-5p, its complement and a sequence at least 95% identical to it, as well as a probe and a vector comprising this
microRNA.
Although most research on EBV has focused on EBV-infected B lymphocytes which harbor the latent viral genome, in fact, much of the immunopathology related to viral infection may occur due to effects on bystander cells through a variety of mechanisms including viral-encoded
microRNA [5,6].