Historically, one theory suggests that
mitochondrion was a bacterium that got caught in a eukaryotic cell two billion years ago.
accumulates faster than a
mitochondrion can repair itself, it becomes
It is important to point out that mitochondrial "dysfunction" does not mean that the
mitochondrion is completely unable to synthetize ATP, but that means the functionality is affected or the organelle is sensitized to insults like calcium overload which is used in some of the experimental protocols; besides, the isolation process itself affects the organelle as can be appreciated with the control group.
Functionally, it was noted that each cell type exhibited heterogeneity in mitochondrial membrane potential (potential ([DELTA][psi]m)), as each cell type examined contained distinct populations of mitochondria having both high or low [DELTA][psi]m, and no single
mitochondrion contained regions of high and low [DELTA][psi]m.
On one hand, the respiratory capacity and the cellular ATP levels are reduced, both key tasks of the
mitochondrion, the powerhouse of the cell At the same time, all cells without HSP60 presented changes.
Manzo-Avalos et al., "Mitochondrial response to oxidative and nitrosative stress in early stages of diabetes,"
Mitochondrion, vol.
The
mitochondrion (plural mitochondria) is a membrane-bound organelle found in most eukaryotic cells (the cells that make up plants, animals, fungi, and many other forms of life).
Wallace Professor of Biomedical Research and chair of comparative medicine at Yale School of Medicine, said that they have found that
mitochondrion need to have ongoing dynamic plasticity in order to support neurons, which are necessary for appetite and for the maintenance of life.
However, quality control against oxidative damage is not restricted to the
mitochondrion itself but is an integrated effort which involves a bidirectional cross talk between the entire mitochondria network and communication with other cellular quality control machineries like autophagy and the ubiquitin proteasomal system.