This model was also used in a pharmacological DTI study in which animals were exposed to rasagiline, a selective
monamine oxidase B inhibitor, as a potential protective agent against thiamine-deficiency-induced brain damage (Dror et al.
The membrane receptors are called vesicular
monamine transporters, or VMAT for short.
2)
Monamine Oxidase Inhibitors (MAOIs): They were also the first medications used to treat "Reactive Depression" and include Phenelzine (Nardil), Selegiline (Emsam) and Tranylcypromine (Parnate).
Exercise caution coadministering other serotonergic medications; do not coadminister with
monamine oxidase inhibitors.
All patients who have received DBS had stage 5 TRD, which meant that their depression was unresponsive to all possible drug classes, including
monamine oxidase inhibitors.
Similarly, the
monamine oxidase type B inhibitor, selegiline, is a neurotropic antioxidant that can be delivered safely via transdermal administration and has been considered as a possible treatment for HIV-associated cognitive decline (Lindl et al., 2010 et al.).