This cycle of refiling, rupture and collapse continues to occur for months.7 Mucocele size ranges from few millimetres to several centimetres across which depends upon its location.There are two patterns histologically,one is an intact epithelium lined duct it dilates and forms a cyst, this is
mucin filled with inflammatory debris or extravasated
mucin in the stroma which has granulation tissue with inflammatory infiltrate and histiocytes.8
On histopathologic review, scleromyxedema is associated with papular and
mucin deposition, and increased fibroblast proliferation.
According to the current WHO classification, these tumors are characterized by round or oval glands with "relative
mucin depletion." Cribriform or papillary architecture may be seen.
One of the genes -- mucin-1 -- makes a sticky protein called
mucin that coats urinary tubes inside the kidney.
Some of the
mucin sugars are similar in structure to the antigens on A- and B-type blood.
On macroscopic examination, the presence of dilatation and perforation, maximum diameter of the specimen, surgical border, and presence of
mucin and on microscopic examination, the level of architectural and cytologic atypia, intactness of the muscularis mucosa, submucosal fibrosis, hyalinization, presence of atrophy in the lymphoid tissue, presence of invasion pushing toward the appendiceal wall, desmoplasia, and presence of single cell invasion were examined by the same pathological experts, who then reached a consensus (Tables 3A, 3B).
A histological examination of the tumor showed overlying thinned-out epidermis, beneath which were seen sheets, cords and nodules of tumor cells lying in the pool of extracellular
mucin (Figure 2A).
Mucin is a protein ordinarily found as part of the dermal connective tissues (1).
(19-21) In the first method, the mucoadhesive property of NP with VRZ was evaluated by measuring the changes of ZP on interaction with negatively charged
mucin. The mucoadhesive NP containing VRZ was incubated at 37[degrees]C in 0.1%
mucin dispersion.
Next, nuclear factor erythroid 2-related factor 2 (Nrf2) was knocked down with Nrf2 small interfering RNA (siRNA) to confirm the specific role of Nrf2 in
mucin regulation of CUR in NCI-H292 cells.