Myelin-related diseases, such as multiple sclerosis, are those where the
myelin sheath surrounding nerves is damaged leading to deficient nerve transmission that may affect multiple functions, including sensation, cognition and movement, among others.
Researchers at the University of Maryland School of Medicine (UMSOM) have discovered that a type of skinrelated stem cell could be used to help regenerate
myelin sheaths, a vital part of the nervous system linked to neurodegenerative disorders.
In a second study, a team from the National Institutes of Health in Bethesda, Md., reports that in mice and rats, brain cells called astrocytes can control how fast nerve cells transmit signals by regulating the thickness of the
myelin sheath that insulates nerve fibers.
In MS, the immune system attacks oligodendrocytes, the cells that create
myelin.
CLEVELAND, Ohio, July 25, 2018 -- Convelo Therapeutics, Inc., a company nurtured in a biotech incubator, has launched with a mission to discover and develop a new class of medicines that regenerate the protective
myelin coating around nerve cells that is lost in various neurological diseases, including multiple sclerosis (MS).
has launched from stealth mode with a mission to discover and develop a new class of medicines that regenerate the protective
myelin coating around nerve cells that is lost in a wide array of neurological diseases, including multiple sclerosis (MS).
No drugs are currently available to repair
myelin, the protective sheath which covers the nerves and becomes damaged with MS.
Myelin alterations in the hippocampus and the PFC were commonly reported in the above-mentioned disorders [14-16].
Much like that bare wire, the nerve fibers in the brain lose their protective coating, called
myelin, and become extremely vulnerable.
Myelin acts as a conductor of signals for the neural circuits.
In the paranodal regions, paranodal
myelin loops bind to the axolemma and form paranodal axo-glial junctions.