The differential diagnoses ranges from benign tumors such as
myxolipoma, myxoid neurofibroma and myxoid leiomyoma to myxofibrosarcoma, myxoid variant of liposarcoma, leiomyosarcoma, malignant fibrous histiocytoma and botryoid rhabdomyosarcoma.
The clinical differential diagnosis includes ranula, dermoid cyst, thyroglossal duct cyst, ectopic thyroid tissue, pleomorphic adenoma and mucoepidermoid carcinoma, angiolipoma, fibrolipoma and malignant lymphoma.9-11 A histopathologic differential diagnosis appropriate to the oral cavity would include fibrosarcoma if spindle cells are not localized and numerous.12 Other lesions should be also considered: they include schwanoma, myxoidneurofibroma, leiomyoma, nodular fasciitis,
myxolipoma, fibrolipoma, malignant fibrous histiocytoma, myxoidliposarcoma, and myxoid solitary fibrous tumor.