Olfaction and mortality Aside from olfaction's potential to predict disease, otherstudies have shown that
olfactory impairment increases the risk of death in older adults.
Olfactory impairment (OI), or poor sense of smell, is an understudied public health problem among older adults.
Uchihara et al., "TDP-43 pathology progression along the olfactory pathway as a possible substrate for
olfactory impairment in amyotrophic lateral sclerosis," Journal of Neuropathology and Experimental Neurology, vol.
In this study we present our data about self-reported
olfactory impairment (SROI) in workers in the abrasive industry professionally exposed to the PRs.
DLB, which has shared clinical symptoms and pathological changes with PDD, is also associated with
olfactory impairment [18].
First, the odor input is transmitted to the olfactory bulb by sensory neurons, which is then decoded and recoded in the piriform cortex and finally flocks together in the hippocampus.[sup][24] Although the mechanisms of AD-related olfactory sensory loss have already been explored through the use of transgenic mouse models[sup][25] and studies have documented olfactory deficits in APP transgenic mice,[sup][26] the role of A[sz] in contributing to AD-related
olfactory impairment and the involvement of these cerebral regions remain largely obscure.
In a cohort study analyzing a group of IPD patients, Postuma and Gagnon identified a significant correlation between episodic verbal memory and
olfactory impairment (6).
In one study, Matthew Growdon, a fourth-year medical student at Harvard University, Boston, and his colleagues found a significant relationship between
olfactory impairment and pathologic markers of AD.
Olfactory impairment is more marked in patients with mild dementia with Lewy bodies than those with mild Alzheimer disease.
Smoking is a strong independent risk factor of
olfactory impairment (3) probably as consequence of anatomical changes that occur in the olfactory mucosa, such as squamous metaplasia (4) and a reduction in the number and size of the olfactory vessels and cilia (5).
"Our findings suggest that while
olfactory impairment may reflect real damage to the sensory system, in some cases it may be a 'use it or lose it' phenomenon," said Dr.
A "scratch and sniff" test is available to assess the degree of
olfactory impairment, but it doesn't help diagnose the cause of the problem, Dr.