Several animal models were developed to study these phenomena, and studies revealed that Zika virus persistence within the male reproductive tract (MRT) results in diminished testosterone and oligospermia (4).
One hundred eighty-seven women (mean age 31.5 years) had unexplained infertility and 52 women (control group) (mean age, 30.1 years) had no other cause of infertility than a partner with sperm abnormalities (azoospermia or severe oligospermia).
The pregnancy was induced by ICSI with ejaculated sperm in another center because of severe oligospermia. Amniocentesis was recommended at the 16th week of pregnancy, but the family refused it.
For instance, more than half of men with testicular cancer present clinically with oligospermia or azoospermia prior to treatment (Hendry et al., 1983; Meirow & Schenker, 1995; van Casteren et al., 2010).
However, studies in animals have shown degeneration in cellular component of seminiferous tubules affecting spermatogenesis (Morris et al, 1993) and in men, some reports of oligospermia outbreak in psoriasis patients, both following undertaking MTX (Badri et al., 2000).
For women with unexplained infertility, thyroid-stimulating hormone (TSH) averaged 1.95 mIU/ mL (95% confidence interval, 1.54-2.61), compared with 1.66 mIU /mL for the group of women with severe male factor infertility, such as severe oligospermia or azoospermia (95% CI, 1.25-2.17; P = .003).
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