Recently, aquaporin 4 has also been identified in the ADH-secreting neurons of the supraoptic and paraventricular nuclei in the hypothalamus that functions as a hypothalamic osmoreceptor and regulates body water balance.
Carlson, "Angiotensin and osmoreceptor inputs to the area postrema: role in long-term control of fluid homeostasis and arterial pressure," Clinical and Experimental Pharmacology and Physiology, vol.
An increase in vascular osmolarity triggers the release of antidiuretic hormone (ADH) from the posterior pituitary, primarily in response to osmoreceptor activation in the hypothalamus (McCance & Huether, 2002).
With advancing age, osmoreceptor sensitivity appears to be maintained [1, 2] or to increase [3], whereas AVP release in response to standing appears to decline [4].
This could be because of inadequate AVP release owing to decreased stores or a change in release mechanism, or because of an inadequate stimulus to AVP release through dysfunction of the osmoreceptor cells.
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