This pathologic entity is reported in the mainstream under various terms: metaplastic/anaplastic carcinoma,
osteoclastoma, or osteoclastic giant cell tumor [2-5].
Giant cell tumor (tumor gigantocellularis,
osteoclastoma) - Epidemiology, diagnosis, treatment.
Osteoclastoma is associated with high morbidity and functional impairment.
Coley, Giant Cell Tumor (
Osteoclastoma), Neoplasms of Bone and Related Conditions, Hoeber, New York, NY, USA, 1960.
Differential diagnoses for MO include osteosarcoma, malignant fibrous histiocytoma, osteochondroma, foreign-body granuloma, giant cell tumor of soft tissue (
osteoclastoma), atypical fibroxanthoma, pseudosarcomatous fibromatosis (nodular fasciitis), and deep vein thrombosis.
The number of documented true giant cell tumors (
osteoclastoma) arising in any of the craniofacial bones is small but they do exist.
The terms of malignant giant cell tumours of soft tissues, giant cell sarcoma, giant cell undifferentiated pleomorphic sarcoma and malignant
osteoclastoma are synonyms used for this variant.[sup.3,4]