Although an association between the prudent clinical use of neomycin/polymyxin B/hydrocortisone otic drops and ototoxicity in humans has not been proven, the perceived risk has led many physicians to switch from using these drops to using topical fluoroquinolone drops such as ciprofloxacin/dexamethasone and ofloxacin.
Topical ciprofloxacin/dexamethasone otic suspension is superior to ofloxacin otic solution in the treatment of granulation tissue in children with acute otitis media with otorrhea through tympanostomy tubes.
The largest collection of (potential) pathogens isolated from external otitis (2) or AOMT (3) has been accumulated and analyzed by Alcon Laboratories during clinical trials of their otic preparations.
In the anti-infective market Alpharma offers a host of products, including Acetasol HC otic solution, which is the company's version of Wallace Laboratories' VoSol HC otic solution; acyclovir oral suspension, the generic equivalent of Glaxo Wellcome Inc.'s Zovirax suspension; cindamycin phosphate topical solution, USP 1%, a generic version of Pharmacia & Upjohn Inc.'s Cleocin topical solution; and Sulfatrim suspension, Alphpharma's version of Monarch Pharmaceuticals' Septra suspension.
Currently, Schroeder is the co-founder, president and CEO of Zavante Therapeutics; A member of the board of Cidara Therapeutics (CDTX) and Otonomy (OTIC); As w ell as chair of BIOCOM, the Southern California Life Sciences organisation.
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