The most commonly used drugs were an injectable (n = 27), a fluoroquinolone (n = 26), cycloserine/terizidone (n = 27), ethionamide/prothionamide (n = 24), and
para-aminosalicylic acid (n = 25).
Twenty years afterward: historical notes on the discovery of the antituberculosis effect of
para-aminosalicylic acid (PAS) and the first clinical trials.
Patients with second-line drug resistance, toxicity, or contraindications to the standardised regimen can access individualised regimens including capreomycin,
para-aminosalicylic acid, clofazimine, linezolid and bedaquiline.
We have developed a nanodelivery formulation based on
para-aminosalicylic acid (PAS) and zinc layered hydroxide using zinc nitrate salt as a precursor.
* Given the high background rates of TB and MDR-TB in several countries, regimens are often constructed around a backbone of capreomycin and
para-aminosalicylic acidIt was reported yesterday that the contract has been signed to produce
Para-Aminosalicylic Acid to be marketed and distributed by Advance Trading.
Rhee's research team exposed TB to
para-aminosalicylic acid (PAS), which was developed more than 50 years ago, and is still part of the multi-drug regimen used to treat resistant TB.
This started with non-pharmacological methods to the discovery of effective medications (streptomycin and
para-aminosalicylic acid) in 1944; the development of "triple therapy" (streptomycin,
para-aminosalicylic acid and isoniazid) in 1952, assured cure.