pen·i·cil·lin·ase

(pĕn′ĭ-sĭl′ĭ-nās′)

Any of several beta-lactamase enzymes that cleave the beta-lactam ring in penicillins. Penicillinases are found in many penicillin-resistant bacteria.

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

penicillinase

(ˌpɛnɪˈsɪlɪneɪz)

(Medicine) any of a group of enzymes used to treat allergic reactions to penicillin

Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

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Noun

penicillinase - enzyme produced by certain bacteria that inactivates penicillin and results in resistance to that antibiotic

beta-lactamase

enzyme - any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions

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References in periodicals archive

In disc diffusion tests, hyper-producers of penicillinase may show small methicillin or oxacillin zones of inhibition, whereas most true methicillin/oxacillin-resistant isolates give no zone.12

Molecular Evaluation of Methicillin Resistant Staphylococcus Aureus Isolates at a Tertiary Care Hospital, Lahore

Furthermore, abscess drainage was not necessary in our patients; therefore, penicillinase resistant penicillin (oxacillin), ampicillin-sulbactam or amoxicillin-clavunate were given as the first choice of treatment in our paediatric patients (8-11).

Preseptal and Orbital Cellulitis in Childhood: The Experience of Ankara Training and Research Hospital

There are different enzymes produced correspondingly against these antibiotics such as penicillinase, cephalosporinases, and carbapenemases22.

DISSEMINATION AND DETECTION OF CARBAPENEMASES PRODUCING GRAM-NEGATIVE RODS

A 25-yearsurvey of antibiotic susceptibility testing in Staphylococcus aureus from bovine mastitis in Belgium, with special reference to penicillinase".

Antibiotic susceptibility profile of bacterial isolates from post-surgical wounds of patients in tertiary care hospitals of Peshawar, Pakistan

Since penicillinase is produced by the ratios of 95% in S.

A Case of Staphylococcal Scalded Skin Syndrome in a 1-Year Old Boy with Otitis Media

6-Aminopenicillanic acid as a substrate for penicillinase and an inducer of penicillinase formation.

The Relationship Between Prevalence of Antibiotics Resistance and Virulence Factors Genes of MRSA and MSSA Strains Isolated from Clinical Samples, West Iran

It has a broad in vitro spectrum of antimicrobial activity against both Gram positive and Gram negative bacteria and is penicillinase resistant [4-12].

Development and Validation of an HPLC-MS/MS Method for Rapid Simultaneous Determination of Cefprozil Diastereomers in Human Plasma

These resistances are related in part to a Ser-91Phe substitution in gyrA for ciprofloxacin (Fluoroquinolones) resistant gonococcal strains, a tetM gene for plasmid-mediated tetracycline resistance (TRNG), and a penicillinase encoding plasmids (Asian, African, Toronto, Rio, Nlmes, New Zealand, and Johannesburg) for plasmid-mediated penicillin resistance (PPNG).

Molecular Antimicrobial Resistance of Neisseria gonorrhoeae in a Moroccan Area

* The first wave began in mid-1940s with emergence of penicillin-resistance, because of plasmid encoded penicillinase that hydrolyses the beta-lactam ring of penicillin essential for its antimicrobial activity.

Emphasis on antibiotic optimisation in difficult to treat methicillin resistant staphylococcus aureus infection

According to the studies, the percentage of methicillin resistant Staphylococcus aureus prevalence is due to different plans of hospitals and the less capability of coupling with penicillin binding proteins for antibiotics with beta-lactam ring and the excess of penicillinase production [22].

Frequency of the Occurence of Methicilin Resistant Staphylococcus aureus (MRSA) Infections in Hyderabad, Pakistan

For patient safety, nurses must review ordered antibiotics to assure no penicillin or penicillinase drugs are administered (Lexicomp, 2015).

Tranexamic acid in total hip arthoplasty: management of complications and use