pep·ti·dase

(pĕp′tĭ-dās′, -dāz′)

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

peptidase

(ˈpɛptɪˌdeɪs; -ˌdeɪz)

(Biochemistry) any of a group of proteolytic enzymes that hydrolyse peptides to amino acids

Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

pep•ti•dase

(ˈpɛp tɪˌdeɪs, -ˌdeɪz)

n.

any of the class of enzymes that catalyze the hydrolysis of peptides or peptones to amino acids.

ThesaurusAntonymsRelated WordsSynonymsLegend:

Noun

peptidase - any enzyme that catalyzes the splitting of proteins into smaller peptide fractions and amino acids by a process known as proteolysis

protease, proteinase, proteolytic enzyme

caspase - any of a group of proteases that mediate apoptosis

enzyme - any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions

angiotensin converting enzyme, angiotensin-converting enzyme, ACE - proteolytic enzyme that converts angiotensin I into angiotensin II

plasminogen activator, urokinase - protease produced in the kidney that converts plasminogen to plasmin and so initiates fibrinolysis

renin - a proteolytic enzyme secreted by the kidneys; catalyzes the formation of angiotensin and thus affects blood pressure

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References in periodicals archive

According to the company, Melflufen is a lipophilic peptide-conjugated alkylator that rapidly delivers a highly cytotoxic payload into myeloma cells through peptidase activity.

Oncopeptides to apply for melflufen's accelerated approval with the US FDA for multiple myeloma

Effects on lipid profile of dipeptidyl peptidase 4 inhibitors, pioglitazone, acarbose, and sulfonylureas: Meta-analysis of placebo controlled trials.

Effect of sitagliptin and glimepiride on C-reactive protein (CRP) in overweight Type-2 diabetic patients

BXCL701 is an orally-available systemic innate-immune activator that inhibits dipeptidyl peptidase 8/9 and FAP developed by BTI.

BioXcel reports Merck KgAA, Pfizer added to collaboration with Nektar

Dipeptidyl peptidase 4-inhibitor (DPP4i) could prevent the inactivation of glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide, thus raising plasma concentrations of the intact, active forms of these peptides and thereby improving islet function by increasing a-cell and [sz]-cell sensitivity to glucose.[1] DPP4i has been used widely for blood glucose control.

Renoprotection Provided by Dipeptidyl Peptidase-4 Inhibitors in Combination with Angiotensin Receptor Blockers in Patients with Type 2 Diabetic Nephropathy

Netherton Syndrome is an autosomal recessive monogenic disease caused by mutations in the SPINK5 gene that encodes a serine peptidase inhibitor.

LifeMax Acquires Worldwide Right to Clinical Stage Orphan Asset

The company's focus is on the development of the lead product candidate Ygalo, an alkylating peptide, Peptidase Enhanced Compounds (PEnCs).

Oncopeptides reports change in number of shares and votes due to warrants exercise

Federici et al., "Effects of dipeptidyl peptidase 4 inhibitors and sodium-glucose linked cotransporter-2 inhibitors on cardiovascular events in patients with type 2 diabetes mellitus: a meta-analysis," International Journal of Cardiology, vol.

Effects of Newer Antidiabetic Drugs on Endothelial Function and Arterial Stiffness: A Systematic Review and Meta-Analysis

[15] Gliptins or dipeptidyl peptidase (DPP)-4 inhibitors could be of some usefulness in non-diabetic individuals, as they act by increasing endogenous insulin secretion, with least hypoglycemic risk.

Evaluation of dipeptidyl peptidase-4 enzyme inhibition by some commonly used gliptins on cutaneous wound healing in albino rats

The team from Kolkata's CSIR-Indian Institute of Chemical Biology, Republic of Korea's Institute for Basic Science (IBS), Kolkata's Vidyasagar College and the Institute of Postgraduate Medical Education and Research (IPGMER) here has in a recent study answered a long standing question as to why diabetics have more amount of an enzyme called dipeptidyl peptidase 4 or DPP4 in their blood.

Scientists stumble upon potential drug target for diabetes

Abbreviations CAD: Coronary artery disease CRP: C-reactive protein CX3CL1: Fractalkine CX3CR1: Fractalkine receptor DPP-4: Dipeptidyl peptidase 4 IL: Interleukin LPS: Lipopolysaccharide MCP-1: Monocyte chemoattractant protein-1 PBMCs: Peripheral blood mononuclear cells T2DM: Type 2 diabetes TNF-[alpha]: Tumor necrosis factor alpha.

A Double-Blinded Randomized Study Investigating a Possible Anti-Inflammatory Effect of Saxagliptin versus Placebo as Add-On Therapy in Patients with Both Type 2 Diabetes And Stable Coronary Artery Disease

KEY WORDS: Homarus americanus, aspartic peptidase, cysteine peptidases, crustacean protein digestion, American lobster

A synergistic peptidase network mediates food protein digestion in the American lobster Homarus americanus (Edwards, 1837)