We moved to a comparison study as a potential treatment for chemotherapy-induced
peripheral neuropathy. We received a grant from the National Institute on Drug Abuse to continue research into CIPN and the potential for a new standard of care, as well as potentially replace opiates as a treatment for CIPN.
Diabetes is one of the most common causes of
peripheral neuropathy, accounting for about 30% of cases.
Susceptible and prognostic genetic factors associated with diabetic
peripheral neuropathy: A comprehensive literature review.
Various conditions lead to
peripheral neuropathy. It affects an estimated 20 million people in the United States.
"Chemotherapy-induced
peripheral neuropathy (CIPN) can interfere with daily function and quality of life, and there are no known preventive approaches," observed Gary R.
Conclusion: As the mutation was found in the healthy samples as well, it can be said that the current mutation AMACR can be involved in some other forms of
peripheral neuropathy which can be with other phenotypes.
Peripheral neuropathy can cause various body discomforts, such as tingling, increased or decreased sensitivity to vibration, hot or cold, numbness, muscle weakness and even burning pain.
"Sometimes people have diabetes that is very long standing, or we may find that a new patient with
peripheral neuropathy has diabetes that has been previously undiagnosed."
Gradual Symptoms
Peripheral neuropathy first affects the longer nerves most distant from the brain and spinal cord, starting in the toes and feet.
Clinical abnormalities consistent with
peripheral neuropathy were common and were observed in about half (50.5 percent) of those treated with neurotoxic chemotherapy (mean Total Neuropathy Score increase, 2.1); these abnormalities correlated with lower limb predominant sensory axonal neuropathy (mean amplitude reduction, 5.8 [micro]V).
Your doctor may have diagnosed you with
peripheral neuropathy. However, did you know that over 20 million Americans suffer from the same symptoms as you?
Peripheral neuropathy (PN) is a common disorder and presents as diagnostic and therapeutic challenge to physicians and neurologists.