phy·so·stig·mine

(fī′sō-stĭg′mēn′) also phy·so·stig·min (-mĭn)

A crystalline alkaloid, C₁₅H₂₁N₃O₂, extracted from the Calabar bean, used in the form of its sulfate as a miotic and in the form of its salicylate as a cholinergic agent. Also called eserine.

[New Latin Phȳsostigma, genus name of the Calabar bean (Greek phūsa, bladder, from the appendage at the end of the stigma that was formerly thought to be hollow + stigma) + -ine.]

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

physostigmine

(ˌfaɪsəʊˈstɪɡmiːn) or

physostigmin

(Elements & Compounds) an alkaloid found in the Calabar bean used esp in eye drops to reduce pressure inside the eyeball. Formula: C15H21N3O2. Also called: eserine

[C19: from New Latin Physostigma genus name, from Greek phusa bladder +stigma mark]

Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

phy•so•stig•mine

(ˌfaɪ soʊˈstɪg min, -mɪn)

n.

an alkaloid, C₁₅H₂₁N₃O₂, used in the treatment of Alzheimer's disease to raise the level of the neurotransmitter acetylcholine.

[1860–65; < New Latin Physostigm(a) genus of plants yielding the alkaloid (< Greek phŷs(a) bladder, bellows + New Latin -o- -o- + stigma stigma) + -ine²]

ThesaurusAntonymsRelated WordsSynonymsLegend:

Noun

physostigmine - used in treatment of Alzheimer's disease and glaucoma

medicament, medication, medicinal drug, medicine - (medicine) something that treats or prevents or alleviates the symptoms of disease

alkaloid - natural bases containing nitrogen found in plants

Translations

physostigmine

n fisostigmina

Mentioned in

References in periodicals archive

Drugs are further segmented into physostigmine, neostigmine, and others.

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Physostigmine is known to prolong neurotransmitters, dilate blood vessels and slow the heartbeat.

Plant of the Week: Poisonous beans were used in Africa to prove witchcraft

cytisine, nicotine and its metabolite cotinine, physostigmine, and

Conium maculatum Intoxication: Literature Review and Case Report on Hemlock Poisoning

From the compounds assigned in vivo to the acute oral toxicity category 1 (fatal if swallowed), three (i.e., brucine, disulfoton, and physostigmine) target the nervous system and act via specific mechanisms (e.g., inhibition of cholinesterase, antagonism of glycine receptor).

Investigating Cell Type Specific Mechanisms Contributing to Acute Oral Toxicity

Scopolamine-induced convulsions in food given fasted mice: effects of physostigmine and MK-801.

Muscarinic M1 and M2 receptors, fasting and seizure development in animals/M1 ve M2 muskarinik reseptorler, aclik ve hayvanlarda nobet gelisimi

For cholinesterase inactivation, physostigmine salicylate (eserine) was added to serum samples prior to the assay.

Oxysterols Increase Inflammation, Lipid Marker Levels and Reflect Accelerated Endothelial Dysfunction in Experimental Animals

The ginseng was given at three different doses: 10, 50, and 100 mg/kg Soares et al., icv injection of 20.3 Fatiguing, constant- 2003 (13); 2004 [micro]M of L-TRP, a speed treadmill (30); 2007 (29) precursor for 5-HT running at 18 m-min synthesis, (5% grade) at 23 [+ immediately before or -] 2[degrees]C the exercise Rodrigues et al., icv injection of 5 x Fatiguing, constant- 2009 (16) [10.sup.-3] M of speed treadmill physostigmine, a drug running at 20 m-min that blocks the (5% grade) at 23 [+ running-induced or -] 2[degrees]C increase in 5-HT in the preoptic area, immediately before the exercise Leite et al., icv injection of 60 Fatiguing, constant- 2010 (32) nmol of losartan speed treadmill immediately before running at 18 m-min the exercise.

Physical exercise-induced fatigue: the role of serotonergic and dopaminergic systems

Use of physostigmine for cyclopentolate overdose in an infant.

Asiri Doz Siklopentolat Oftalmik Solusyon Uygulamasina Bagli Pediyatrik Intoksikasyon Olgusu/A Case of Pediatric Intoxication Due to Overdose Cylopentolate Ophthalmic Solution Application

Effects of oral physostigmine and lecithin on memory and attention in closed head-injured patients.

Nutraceuticals for traumatic brain injury: should you recommend their use? Although commonly used in clinical practice, evidence for their use in TBI is preliminary

Physostigmine therapy is recommended in severe clinical states such as malignant dysrhythmias, coma, respiratory failure requiring mechanical ventilation, and uncontrolled hyperthermia.

Datura Stramonium Poisoning: Two Case Reports

Thomas, "Interactive effects of light/dark cycle, ECS, physostigmine, and scopolamine on one-way avoidance learning in rats," Physiological Psychology, vol.

Circadian Rhythms in Fear Conditioning: An Overview of Behavioral, Brain System, and Molecular Interactions

Eadie, "The inhibition of cholinesterase by physostigmine and prostigmine," The Journal of Biological Chemistry, vol.

Robust Nonlinear Regression in Enzyme Kinetic Parameters Estimation