pi·per·a·cil·lin

(pī-pĕr′ə-sĭl′ĭn)

A semisynthetic broad-spectrum penicillin, C₂₃H₂₇N₅O₇S, used in its sodium form often in combination with the beta-lactamase inhibitor tazobactam, and active against a variety of gram-positive and gram-negative bacteria.

[pipera(zine) + (peni)cillin.]

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

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Noun

piperacillin - a synthetic type of penicillin antibiotic (trade name Pipracil) used for moderate to severe infections

Pipracil

penicillin - any of various antibiotics obtained from Penicillium molds (or produced synthetically) and used in the treatment of various infections and diseases

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References in periodicals archive

Though EMA was "a great regulatory body" and the GMP review an important initiative overall, piperacillin shortages should be avoided because second-choice drugs would put patients' lives at risk from avoidable infections, he argued.

Tighter EU rules could trigger antibiotic shortage

The study developed statistical methods to predict phenotypic resistance from resistance genes for various combinations of the four bacterial species and the antibiotics gentamicin, tobramycin, ciprofloxacin, levofloxacin, trimethoprim-sulfamethoxazole, ertapenem, imipenem, cefazolin, cefepime, cefotaxime, ceftazidime, ceftriaxone, ampicillin, piperacillin and aztreonam.

OpGen announces publication of data on antibiotic resistance using Acuitas

Here, is a case of SJS-type reaction secondary to piperacillin in surgical ICU at AFIC/NIHD.

POST OPERATIVE STEVEN JOHNSON TYPE REACTION SECONDARY TO PIPERACILLIN

coli isolates, the sensitivity pattern towards, Cefepime Tazobactam was 90%, Cefepime--32%, Piperacillin Tazobactam -75%, Cefoperazone sulbactam 71%, Carbapenem- 91%, and Amikacin- 92%.

ANTIMICROBIAL SENSITIVITY OF GRAM-NEGATIVE BACTERIA WITH BETA LACTAM /BETA LACTAMASE INHIBITOR COMBINATION OF DRUGS IN COMPARISON TO OTHER ANTIBIOTICS IN TERTIARY CARE CENTER

(20) The following antimicrobial agents were examined: amikacin (30 [micro]g), aztreonam (30 [micro]g), cefepime (30 [micro]g), cefotaxime (30 [micro]g), ceftazidime (30 [micro]g), cefuroxime (30 [micro]g), ciprofloxacin (5 [micro]g), colistin (10 [micro]g), gentamicin (10 [micro]g), imipenem (10 [micro]g), meropenem (10 [micro]g), piperacillin (100 [micro]g), piperacillin/tazobactam (110 [micro]g), tobramycin (10 [micro]g), and trimethoprim/sulfamethoxazole (23.75 [micro]g/1.25 [micro]g).

High antimicrobial resistant rates among Gram-negative pathogens in intensive care units: A retrospective study at a tertiary care hospital in Southwest Saudi Arabia

Piperacillin-tazobactam (PTZ) is a combination of piperacillin and the blactamase inhibitor tazobactam.

Acute Kidney Injury in Pediatric Treated with Vancomycin and Piperacillin-Tazobactam in Tertiary Care Hospital

parvulum Penicillin S Ampicillin S Amoxicillin/clavulanate S Piperacillin S Piperacillin/tazobactam S Metronidazole S Imipenem S Meropenem S Clindamicyn S Vancomycin S

Necrotizing Fasciitis by Two Anaerobic Bacteria in an Immunocompetent Patient after Minor Trauma: A Case Report

Pseudomonas aeruginosa Correlation p value Correlation p coefficient (r) coefficient (r) value Total antibiotics -0.393 0.383 -0.252 0.585 Piperacillin 0.739 0.058 -0.345 0.448 /tazobactam Ampicillin -0.571 0.180 -0.162 0.728 /sulbactam Third generation 0.643 0.119 0.198 0.670 of cephalosporins Carbapenems 0.500 0.253 0.126 0.788 Tigecycline 0.821 0.023 -0.018 0.969 Aminoglycosides -0.857 0.014 0.054 0.908 Fluoroquinolones 0.429 0.337 -0.162 0.728 Colistin 0.643 0.119 0.270 0.558 TABLE 3.

Previous Antibiotic Exposure and Antimicrobial Resistance Patterns of Acinetobacter spp. and Pseudomonas aeruginosa Isolated from Patients with Nosocomial Infections

pneumoniae Kp81 Amikacin [greater than or equal to] 64 (R) Aztreonam [greater than or equal to] 64 (R) Cefepime [greater than or equal to] 64 (R) Ceftazidime [greater than or equal to] 64 (R) Ciprofloxacin [greater than or equal to] 4 (R) Colistin [less than or equal to] 0.5 (S) Gentamicin [greater than or equal to] 16 (R) Imipenem [greater than or equal to] 16 (R) Meropenem [greater than or equal to] 16 (R) Piperacillin [greater than or equal to] 128 (R) Piperacillin/tazobactam [greater than or equal to] 128 (R) Ticarcillin [greater than or equal to] 128 (R) Ticarcillin/clavulanic acid [greater than or equal to] 128 (R) Tigecycline 1.5 (S) Tobramycin [greater than or equal to] 16 (R) Trimethoprim/sulfamethoxazole [greater than or equal to] 320 (R) Drug MIC, mg/L (susceptibility) E.

Mcr-1 and [bla.sub.KPC_3] in Escherichia coli sequence Type 744 after meropenem and colistin therapy, Portugal

In a pilot study, piperacillin (87 mg/kg) in combination with tazobactam (11 mg/kg) was administered intramuscularly (IM) to 2 birds, and blood samples were obtained at 0, 0.5, 1, 1.5, 2, 3, 4, 6, 8, and 10 hours after administration.

Single-dose pharmacokinetics of piperacillin/tazobactam in Hispaniolan Amazon Parrots (Amazona veniralis)

cefixime, ceftazidime, co-trimoxazole, ciprofloxacin, gentamicin, amikacin, cefoperazone + sulbactam, piperacillin + tazobactam, meropenem, polymyxin - B, and aztreonam were used.

Microbial profile and antibiotic susceptibility pattern of orthopedic infections in a tertiary care hospital: a study from South India