Evidence was seen for
pleiotropic relationships, notably correlations for chronic lymphocytic leukemia with elevated familial risk of other B cell tumors and myeloproliferative neoplasms.
NRP2 is a
pleiotropic cell surface receptor that plays a key role in lymphatic development and in regulating inflammatory responses.
"The presence of variants in PAD13 in both CCCA and uncombable hair syndrome suggests that this gene has a
pleiotropic effect on the determination of hair texture, and the finding holds implications for future development of therapy, such as the restoration of PAD 13 activity," he concluded.
qSY-3 might had
pleiotropic effects on various parameters.
Cardax CEO David G Watumull said, 'We have long thought that natural products with
pleiotropic mechanisms of action can safely address unmet medical needs in chronic disease.
Statins are cholesterol-lowering drugs that exert
pleiotropic effects including suppression of oxidative stress.
Cytokines are
pleiotropic and function by promoting or suppressing a variety of cellular functions, including inflammatory responses.
Use of Statins: Statins have not only effects on lipids but have
pleiotropic effects like anti-inflammatory, anti-oxidants, anti-thrombotic and cardio-metabolic effects.
Although fluvastatin is less potent than pravastatin with regard to lipid-lowering effects, the differences in
pleiotropic effects among statins remain unclear because there are insufficient data.
Comparative effects of 10-mg versus 80-mg atorvastatin on high-sensitivity C-reactive protein in patients with stable coronary artery disease: results of the CAP (Comparative Atorvastatin
Pleiotropic effects) study.
Mutations at the KIT locus can lead to
pleiotropic developmental defects in pigment cells, and KIT activation impacts blood cells (Geissler et al., 1988; Haase et al., 2010).