M2 PHARMA-August 28, 2019-Emtora Biosciences Awarded USD 3m CPRIT Grant to Study Efficacy of eRapa in Familial Adenomatous
PolyposisIn the U.S., Dupixent is currently approved in patients 12 years and older with moderate-to-severe atopic dermatitis, as well as moderate-to-severe asthma and adults with severe chronic rhinosinusitis with nasal
polyposis." The topline data show that for children with severe atopic dermatitis, adding Dupixent to standard-of-care topical corticosteroids, or TCS, significantly improved measures of overall disease severity, skin clearing, itching and health-related quality of life, compared to TCS alone.
The approval enables the companies to use the product with other medicines for the treatment of chronic rhinosinusitis with nasal
polyposis in adults whose disease is not controlled.
Hereditary CRC can be phenotypically divided into two types: non-polyposis associated and
polyposis associated--the latter including polyps that are either adenomas or hamartomas.
To develop the guideline, they searched the literature for studies of family history and colorectal cancer risk apart from hereditary Lynch syndrome, familial adenomatous
polyposis, attenuated familial adenomatous
polyposis, MUTYH-associated
polyposis, Peutz-Jeghers syndrome, juvenile
polyposis syndrome, Cowden syndrome, serrated (hyperplastic)
polyposis syndrome, hereditary pancreatic cancer, and hereditary gastric cancer.
The aim of the present study was to determine the prevalence of long-term mucocele development after functional endoscopic sinus surgery (FESS) for nasal
polyposis, to search for a statistical relationship with preoperative variables and to analyze the management of this complication.
Historically, allergy has been implicated in the pathogenesis of NP as the symptoms of allergy; nasal drip and mucosal edema were seen in patients of nasal
polyposis as well2,3.
The presence of numerous, relatively large polyps coalescing in a localized segment of the intestine are described as a giant inflammatory
polyposis. This inflammatory
polyposis can be misdiagnosed as tumor-like proliferation and be revealed by the development of intestinal obstruction or sub-obstruction, as in our case (2).
[3] Nasal
polyposis is the most common chronic disease affecting the mucous membranes of the nasal cavity and the PNS, and following chronic sinusitis it is the most frequent indication for surgical intervention in the nose and PNS.
This model is particularly interesting because it resembles human familial adenomatous
polyposis, a condition that carries an 80 per cent risk of developing colorectal cancer in individuals with mutations in a tumour suppressor gene called Apc, the study suggested.
Several types of hereditary
polyposis syndromes have been described among hereditary CRC syndromes, including familial adenomatous
polyposis (FAP), MUTYH-associated
polyposis (MAP), familial juvenile
polyposis, serrated
polyposis, and Peutz-Jeghers syndrome (3, 4).