Pregnanediol, pregnanetriol, and cortisol metabolites concentrations were within reference ranges.
Both groups had significant increases in several steroid metabolites compared with the Lupron alone condition after treatment with E2 (that is, estrone-S04 (q=0.039 and q=0.002, respectively) and estradiol-3-S04 (q=0.166 and q= 0.001, respectively)) and after treatment with P4 (that is, allopregnanolone (q=0.001 for both PMDD and controls),
pregnanediol (q=0.077 and q=0.030, respectively) and cortexone (q=0.118 and q=0.157, respectively).
One study compared self-report of cycle day with urinary
pregnanediol concentrations to demonstrate that over 30% of women presenting for ECPs had inaccurately dated their own menstrual cycles, believing themselves to be in the fertile phase of their cycle when they were not.
The women in the Yusho cohort were found to have irregular menstrual cycles and low urinary excretion of estrogens,
pregnanediol, and pregnantriol (Tsukamoto, Makisumi, & Hirose, 1969).
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Pregnanediol glucuronide measurements indicated that "escape" ovulation occurred more often in the 21-7 cyclic group.
Urinary luteinizing hormone (LH) and
pregnanediol glucuronide (PDG), a progesterone metabolite, were assessed to determine if treatment with simvastatin adversely affects luteal function.
One study in which women received 1.6 mg of levonorgestrel on day 10 of their cycle showed that the treatment seemed to suppress the midcycle luteinizing hormone peak (which induces ovulation), but did not appear to influence the formation and function of the corpus luteum, since the urinary excretion of
pregnanediol (the main metabolite of progesterone) was normal.
The system involves a 5-minute urine test that measures the presence of the hormone metabolite
pregnanediol glucuronide (PDG), which corresponds to the time when women are considered to be in the postovulatory nonfertile period (and thus are biologically unable to become pregnant).
(24) This shows up quite clearly in the comparison of
pregnanediol levels in 24-hour Urine and Dry Urine profiles.