The other major step by the panel was to add primaquine as a sixth option for primary prophylaxis, although it is a secondline drug because of its potentially serious adverse effects.
Subsequently, a screen for glucose-6-phosphate dehydrogenase (G6PD) deficiency was negative (a requirement for primaquine), and a 14-day course of primaquine (30 mg daily) was administered.
Oral quinine sulphate 600 mg TDS was started on Day 4 for a total of 7 days along with a single dose of 45 mg primaquine. Patient was discharged on Day 10 with complete recovery.
In vivo therapeutic efficacy of chloroquine alone or in combination with primaquine against vivax malaria in Kolkata, West Bengal, India, and polymorphism in pvmdrl and pvcrt-o genes.
One such intervention, which is endorsed by the WHO, [44] is to treat all positive malaria cases with a single dose of primaquine. This drug efficiently inactivates gametocytes but in persons with genetically determined glucose-6-phosphate dehydrogenase (G6PD) enzyme deficiency of red blood cells, it may cause haemolysis and subsequent anaemia of variable severity.
Chloroquine was unavailable, so the patient was re-treated with oral hydroxychloroquine with an 800-mg loading dose, followed by 400 mg at 6 hours, 400 mg at 24 hours, 400 mg at 48 hours, and a single 45-mg dose of oral primaquine. The parasite count declined rapidly to 37/[micro]L at 28 hours, 191/[micro]L at 49 hours, and 76/[micro]L at 88 hours of treatment.
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