pro·ta·mine

(prō′tə-mēn′, -mĭn) also pro·ta·min (-mĭn)

Any of a group of arginine-rich proteins that bind to and package DNA in the sperm nucleus. Protamines are used in long-acting formulations of insulin and to neutralize the anticoagulant effects of heparin.

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

protamine

(ˈprəʊtəˌmiːn)

(Biochemistry) any of a group of basic simple proteins that occur, in association with nucleic acids, in the sperm of some fish

[C19: from German: see proto-, amine]

Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

prot•a•mine

(ˈproʊ təˌmin, prɒˈtæm ɪn)

n.

any of a group of arginine-rich, strongly basic proteins that are not coagulated by heat.

[1870–75]

ThesaurusAntonymsRelated WordsSynonymsLegend:

Noun

protamine - a simple protein found in fish sperm; rich in arginine; simpler in composition than globulin or albumin; counteracts the anticoagulant effect of heparin

simple protein - a protein that yields only amino acids when hydrolyzed

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References in periodicals archive

In this poster Goldfinch Bio researchers demonstrated that TRPC5 nanomolar inhibitory activity, selectivity across other TRP channels and TRPC subtype specificity; prevention of the loss of stress fibers that are critical in maintaining kidney function, including protection against protamine sulfate induced loss of stress fibers and restoration of stress fibers in podocytes after knockdown of synaptopodin; suppression of pathogenic podocyte motility in a scratch assay; and amelioration of proteinuria in hypertension-induced FSGS in relevant preclinical models without altering blood pressure.

Goldfinch Bio Names GFB-887 as Clinical Development Candidate and Presents Data Demonstrating Selective Inhibition of TRPC5 for the Treatment of Genetically-driven Kidney Disease

At the end of the operation, we would not neutralize heparin with protamine sulfate. Stump pressure, TCD, and electroencephalography were monitored during the intact procedure in all patients.

Evaluation of Clinical Efficacy and Surgical Strategy for 1000 Cases of Carotid Endarterectomy

Due to the recent history of LMWH treatment, protamine sulfate was also administered but with no results.

Successful Outcome of Severe Intra-cerebral Bleeding Associated with Acquired Factor V Inhibition: Utilization of Multiple Therapeutic Agents

We did not have aminocaproic acid as a specific antidote to fibrinolytic agents, so for coverage of all aspects of coagulation pathways we decided to prescribe fresh frozen plasma (FFP) and platelets, in conjunction with protamine sulfate and tranexamic acid.

Iatrogenic IVC Perforation after Successful Catheter-Directed Thrombolysis

Insulin lispro protamine, a component of premix Humalog, is, by itself, an intermediate-acting blood glucose lowering agent that is produced by combining insulin lispro and protamine sulfate under appropriate conditions for crystal formation.

Innovations in insulin for type 2 diabetes mellitus

Mismanagement of heparin anticoagulation and subsequent reversal with protamine sulfate is a common contributor of coagulopathic bleeding in the perioperative setting.

Clinical application of thromboelastometry in cardiovascular and thoracic surgery

Protamine sulfate is a cationic polypeptide derived from salmon sperm that can bind negatively charged unfractionated heparin (UFH)15.

COMPARISON OF TOPICAL USE OF PROTAMINE AND TRANEXAMIC ACID IN SURGICAL PATIENTS REQUIRING CARDIO-PULMONARY BYPASS

Polycation TAs are macromolecular substances with positively charged surfaces that may include polylysine20 or protamine sulfate.18 With a strong positive/negative interaction SPIO/TA composites are able to adhere to the surface of cell membranes improve the phagocytosis of iron oxide particles and avoid aggregation of SPIO particles.21 For example Frank and colleagues mixed Ferumoxides (Feridex) with USPIO (MION-46 L) and added cationic TAs successfully raising the concentration of intracellular SPIO particles.

MRI tracking stem cells transplantation for coronary heart disease

Methods of characterizing the individual phases of blood coagulation: prothrombin time; thrombin time; clotting fibrinogen; antithrombin III (AT III), protamine sulfate test, ethanol test.

Bioregulatory basic peptides liberated from gall-bladder inflammatory wall of people who are sick with acute cholecystitis after laparatomy cholecystectomy

Protamine sulfate binds to negatively charged unfractionated heparin.

Changes in activated partial thromboplastin time and international normalised ratio after on-pump and off-pump surgical revascularization of the heart