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Pyknosis and loss of neurons, especially of pyramidal cells may be related, apparently, with the action of ethanol and drugs.

The condition of hemato and liquor-encephalic barriers of the human brain in acute blood loss on the background of alcoholemia and drug intoxication

Pyknosis, or shrunken nuclei, are characterized by a small shrunken nucleus, with a high density of nuclear material that is uniformly but intensely stained.

Micronucleus as potential biomarker of oral carcinogenesis

Farley (1969) mentioned "increased sarcomatoid cell pyknosis" in disseminated neoplasia of mussels that possibly referred to apoptotic chromatin condensation.

Several cases of disseminated neoplasia in mussels Mytilus edulis (L.) in western Long Island Sound

At the cellular level, the tubular cells showed pyknosis and cytoplasmic lysis (Fig.

Thermal Effect of Acute and Chronic Stress on Hepatic and Renal Tissue of the Pacific Sardine, Sardinops sagax caeruleus (Jenyns, 1842)/ Efecto del Estres Termico Agudo y Cronico Sobre el Tejido Hepatico y Renal de la Sardina del Pacifico, Sardinops sagax caeruleus (Jenyns, 1842)

Apoptotic cell nuclei presented in dark brown, the cytoplasm showed no color and the cell nuclei showed pyknosis. TUNEL-positive cells in the slices of each group could be seen in the light microscope.

Protective effects of fentanyl preconditioning on cardiomyocyte apoptosis induced by ischemia-reperfusion in rats

On H&E-stained sections, neuronal pyknosis, swelling, torsion, and cell body deformation were present in rat cortex of DAI 3 d group while, in the control group, no similar abnormal histopathological changes were observed (Figure 1).

Involvement of Toll Like Receptor 2 Signaling in Secondary Injury during Experimental Diffuse Axonal Injury in Rats

Later changes include necrotic changes (pyknosis and karyorrhexis of trophoblast), loss of trophoblast nuclear staining, and eventually ghost villi.

Sampling and Definitions of Placental Lesions: Amsterdam Placental Workshop Group Consensus Statement

However, the hippocampal neurons in the model group exhibited clear pyknosis, nuclear invagination, karyorrhexis and increased numbers of lysosomes.

The effect of ethyl acetate extract from persimmon leaves on Alzheimer's disease and its underlying mechanism

Our findings are also in accordance with Abdel-Gawad S K & Mohamed A K G (9) who observed that PCT was most severely affected followed by DCT in the form of vacuolated cytoplasm and necrotic changes in the form of nuclear pyknosis along with intratubular casts with desquamated renal tubular cells.

Histomorphological effects of cisplatin on kidney of male Wistar albino rats