'Understanding the
renal clearance of ELX-02 provides important information about the appropriate dose adjustments for patients with renal impairment or increased clearance,' said Dr.
The choice of chemotherapeutic agents should take into account the drugs'
renal clearance and potential renal and non-renal toxicity (20).
Hyperthyroidism in cats may cause an increase in phosphate, as thyroxin (thyroid hormone) can interfere with
renal clearance of phosphate.
Renal clearance is calculated by the following formula: [C.sub.s] (mL/min) = Us (mg/mL) x V (mL/min)/[P.sub.s] (mg/mL) where C, equals the clearance of substance s, [U.sub.s] reflects the urinary concentration of s, V represents the urinary flow rate, and Ps equals the plasma concentration of s.
Ribavirin metabolites cause hemolysis by accumulating in the erythrocytes due to low
renal clearance. It can be used in patients with stage 1 and 2 CRFs with dose adjustment but is not recommended for use in stages 3, 4, and 5 and hemodialysis patients (20).
The current study was planned to assess the pharmacokinetics,
renal clearance and urinary excretion of cefixime in healthy young volunteers to understand the contribution of factors such as age, genetic and environmental variability in the pharmacokinetics,
renal clearance and urinary excretion of cefixime in indigenous conditions.
There was no significant difference observed between male and female hyperuricemia prevalence in CKD population which may be because of low estrogen level that has a role in
renal clearance of uric acid level14.
Lead PROAC VE-1902, which is currently in a phase I clinical trial, was well-tolerated in regulatory toxicity studies and demonstrated low
renal clearance, a desirable property for patients with impaired kidney function.
According to the clinical-stage company, VE-1902 was well-tolerated in regulatory toxicity studies and had shown low
renal clearance, which is a desirable property for patients with impaired kidney function.
Studies have shown that up to 61% of critical patients do not reach the target trough concentration (≥15 mg/L) when administered conventional therapy that includes vancomycin,[5] which might be due to the fact that many patients with severe symptoms display augmented
renal clearance (ARC) and high ARC has been correlated with a markedly insufficient vancomycin dosage.[6],[7] Moreover, the concentration of vancomycin in lung tissues is far below that in blood, and this finding might be responsible for its poor efficacy.
Also, electrolyte imbalances can occur, particularly in older patients with
renal clearance issues.