The French pharmaceutical company's lead product, ADV7103, has achieved positive results in Europe in a pivotal Phase III study of distal Renal Tubular Acidosis in children and adults, leading to its recent submission for European marketing authorization.
Angiotensin II is essential for the secretion of aldosterone [5] with ACE-I can produce a variable degree of hyporeninemic hypoaldosteronism or type IV renal tubular acidosis [6-10] characterized by metabolic acidosis and hyperkalaemia due to aldosterone deficiency.
Most common form of renal involvement in Sjogren's syndrome is interstitial nephritis followed by distal renal tubular acidosis (dRTA), nephrogenic diabetes insipidus, and different forms of glomerular diseases, of which membranoproliferative glomerulonephritis (MPGN) and membranous nephropathy (MN) are the most common [3, 4].
A primary Sjogren's syndrome patient with distal renal tubular acidosis, who presented with symptoms of hypokalemic periodic paralysis: Report of a case study and review of the literature.Rheumatol Int 2005;26:86-89
Sawa et al., "Autoantibodies against carbonic anhydrase II are increased in renal tubular acidosis associated with Sjogren syndrome," American Journal of Medicine, vol.
Findings of metabolic acidosis and alkalosis (each in 2 cases) has lead to diagnosis of renal tubular acidosis and Bartter syndrome though children were admitted with primary malnutrition.24 Electrolyte abnormalities and Bartter syndrome were also found in our previous study on morbidity patterns in children with SAM.
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